<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-2025 2025-30429 Netherlands 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, M184V, L210W, T215Y A62V, V75I     I31L, V35VM, T39A, K43E, A98S, V118VI, S162A, G196E, L228H, T286A, A288G, P345Q, R358K, A371T, T386I, K390R, E399D  
>2025-30429| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKLKALMEICAELEEEGKISKIGPENPYNTPV
FVIKKKDSTKWRKLIDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSIPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIEQHRTKIEELRQHLWRWGFYTPDKKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKGLTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEQFKNLKTGKYARMKGA
HTNDVKQLTETVQKIATESIVIWGKIPKFRLPIQKETWDA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A, L90M L33F, K43T, G73S L10I, E34Q, M36L, I62V, L63P, A71V, I72K, I85V, I93L  
>2025-30429| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVFQELNLPGRWTPKIIGGIGGFVKVRQYD
QVPIEICGHKVKSTVLVGPTPANIVGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006