Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2025 | 2025-30429 | Netherlands | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | L33F, K43T, G73S | L10I, E34Q, M36L, I62V, L63P, A71V, I72K, I85V, I93L |
| >2025-30429| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVFQELNLPGRWTPKIIGGIGGFVKVRQYD QVPIEICGHKVKSTVLVGPTPANIVGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | A62V, V75I | I31L, V35VM, T39A, K43E, A98S, V118VI, S162A, G196E, L228H, T286A, A288G, P345Q, R358K, A371T, T386I, K390R, E399D |
| >2025-30429| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKLKALMEICAELEEEGKISKIGPENPYNTPV FVIKKKDSTKWRKLIDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLWRWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKGLTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEQFKNLKTGKYARMKGA HTNDVKQLTETVQKIATESIVIWGKIPKFRLPIQKETWDA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |