Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2021 | 2021-30507 | Netherlands | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184MV, L210W, T215Y | N348I | K103N | L234LI | V35T, T200E, Q207A, R211K, L228R, V245KN, A272AP, I293V, D324E, I329V, Q334L, F346H, M357MV, R358K, E370G, A376S, S379SC, K390R |
| >2021-30507| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHREKIEELRAHLWKWGFYTPDKKHQKEPPFRWMGYEIHPDKWT VQPINLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKELIAEVQKQGLGQWTYQIYQEPHKILKTGKYARVKGA HTNDVKQLTGAVQKISTECIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48LV, I54S, V82A | L33F, Q58E | L10I, I62V, L63P, A71V, V77I, I93L |
| >2021-30507| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVFEEMNLPGRWKPKIIVGIGGFSKVREYD QVPIEICGHKVIGTVLIGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |