Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2020 | 2020-30915 | Netherlands | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54T, V82A, I84V | L33F, M46V, Q58E | L10I, I13IV, K20R, E35D, M36I, P39PS, R41K, I62V, L63P, A71V, V77T, I93L | E34HKNQ |
| >2020-30915| codons 1-99 PQITLWQRPIVTVKIGGQLREALLDTGADDTVFQDINLSGKWKPKVIVGIGGFTKVREYD QVPIEICGHKVIGTVLTGPTPANVIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, M184V, L210W, T215Y | K101KE | V108VI | K20KR, V35VI, T39TK, K43E, E44D, V118I, K122E, D177G, I178IM, G196E, T200A, E203K, Q207DE, H208Y, R211KQ, K223T, A272P, K277R, T286A, I293V, E297R, G333E, G359S, A371V, T377IV, S379SC |
| >2020-30915| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICKELEEDGKISKIGPENPYNTPV FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPGMVI YQYVDDLYVGSDLEIEQHRAKIKELREYLWQWGFYTPDKKHQTEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVVPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQEQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKIAVECIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |