<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-2020 2020-30915 Netherlands 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I54T, V82A, I84V L33F, M46V, Q58E L10I, I13IV, K20R, E35D, M36I, P39PS, R41K, I62V, L63P, A71V, V77T, I93L E34HKNQ
>2020-30915| codons 1-99
PQITLWQRPIVTVKIGGQLREALLDTGADDTVFQDINLSGKWKPKVIVGIGGFTKVREYD
QVPIEICGHKVIGTVLTGPTPANVIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L74V, M184V, L210W, T215Y   K101KE V108VI K20KR, V35VI, T39TK, K43E, E44D, V118I, K122E, D177G, I178IM, G196E, T200A, E203K, Q207DE, H208Y, R211KQ, K223T, A272P, K277R, T286A, I293V, E297R, G333E, G359S, A371V, T377IV, S379SC  
>2020-30915| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICKELEEDGKISKIGPENPYNTPV
FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTILDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPGMVI
YQYVDDLYVGSDLEIEQHRAKIKELREYLWQWGFYTPDKKHQTEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVVPLTREAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQEQGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVKQLTEVVQKIAVECIVIWGKTPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006