<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-2019 2019-30630 Netherlands 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, I54V, V82S K43T, F53L L10I, I15V, L19I, E35D, M36L, N37D, K55R, I62V, L63P, A71I, I85V L38Y
>2019-30630| codons 1-99
PQITLWQRPIVTIKVGGQIKEALLDTGADDTVLEDLDYPGRWTPKIVGGIGGLVRVRQYD
QVPIEICGHKIIGTVLVGPTPSNIVGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L210W, T215Y       V35L, K43N, E44D, W88C, V118I, D123E, Q174R, D177E, I178F, T200A, E203D, Q207E, H208Y, R211K, L228H, K277R, Q278H, T286A, I293V, E297A, Q334E, G359S, K366R, A376S, T377L  
>2019-30630| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICTELENDGKISKIGPENPYNTPV
FAIKKKNSDKWRKLVDFRELNKRTQDFCEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPEFVI
YQYMDDLYVGSDLEIGQHRAKIDELREYLWKWGFYTPDKKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRHLCKLLRGAKALTEVVPLTAEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVRQLTEAVQKISLESIVIWGKTPKFKLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006