Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2019 | 2019-30630 | Netherlands | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, V82S | K43T, F53L | L10I, I15V, L19I, E35D, M36L, N37D, K55R, I62V, L63P, A71I, I85V | L38Y |
| >2019-30630| codons 1-99 PQITLWQRPIVTIKVGGQIKEALLDTGADDTVLEDLDYPGRWTPKIVGGIGGLVRVRQYD QVPIEICGHKIIGTVLVGPTPSNIVGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215Y | V35L, K43N, E44D, W88C, V118I, D123E, Q174R, D177E, I178F, T200A, E203D, Q207E, H208Y, R211K, L228H, K277R, Q278H, T286A, I293V, E297A, Q334E, G359S, K366R, A376S, T377L |
| >2019-30630| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICTELENDGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFCEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPEFVI YQYMDDLYVGSDLEIGQHRAKIDELREYLWKWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRHLCKLLRGAKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVRQLTEAVQKISLESIVIWGKTPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |