Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2018 | 2018-30514 | Netherlands | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54T, V82A | K43KT | L10I, N37ND, D60E, Q61DE, L63P, H69HQ, A71I, V77I, I93M |
| >2018-30514| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWTPKMIVGIGGFTKVRQYE EIPIEICGQKIIGTVLIGPTPANIIGRNLLTQMGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K43N, E44D, V118I, D121H, K122E, I135IV, I142IV, S162D, D177E, V179VI, H208HY, R211K, T286TA, I293V, M357MT, A360T, K390R |
| >2018-30514| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL HEDFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPEIII YQYVDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGT HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |