Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2017 | 2017-30514 | Netherlands | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, T215F | K219Q, N348I | Y181C | V35M, T39TA, K122E, T139TR, I142IV, D177E, V179I, Q207D, R211K, D218DE, L228Q, E291D, I293V, E297Q, I329L, R358K, A376T, K390R |
| >2017-30514| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNERPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIII CQYVDDLYVGSDLEIGQHRTKIEELRDHLLKWGFFTPEQKHQKEPPFQWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTDVVPLTQEAE LELAENREILKEPVHGVYYDPSKDLIAELQKQGQGQWTYQIYQEPFKILKTGKYARMKGA HTNDVKQLTEAVQKITTESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82A, L90M | L5LF, L10I, L19I, K20R, E35D, M36I, R41K, D60E, I62V, L63P, A71V, I72IV, I93L |
| >2017-30514| codons 1-99 PQITFWQRPIVTIKIGGQIREALLDTGADDTVLEDINLPGKWKPKIIGGIGGFVKVRQYE QVPIEICGHKVVGTVVVGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |