<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-2014 2014-30512 Netherlands 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y K219N   A98G, V108I K20R, V21I, V35I, K43E, E44A, V118I, K122P, D123E, I142V, T165I, D177E, H208Y, R211K, K223E, L228H, A272P, K277R, I293V, E297R, A360T  
>2014-30512| codons 1-399
PISPIETVPVKLKPGMDGPRIKQWPLTEEKIKALIEICTELEEAGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTILDVGDAYFSIPL
DPEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMIKILEPFRKQNPEIVI
YQYVDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTPDNKHQEEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTREAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGT
HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, I84V, L90M L33IV, L89V L10I, L19P, K20I, M36I, L63P, I66IV, A71V, I72L, I85V, Q92K  
>2014-30512| codons 1-99
PQITLWQRPIVTIKIGGQPIEALLDTGADDTVVEEINLPGRWKPKLIGGIGGFVKVRQYD
QIPIEVCGHKVLGTVLVGPTPVNVVGRNVMTKIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006