Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2014 | 2014-30512 | Netherlands | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, I84V, L90M | L33IV, L89V | L10I, L19P, K20I, M36I, L63P, I66IV, A71V, I72L, I85V, Q92K |
| >2014-30512| codons 1-99 PQITLWQRPIVTIKIGGQPIEALLDTGADDTVVEEINLPGRWKPKLIGGIGGFVKVRQYD QIPIEVCGHKVLGTVLVGPTPVNVVGRNVMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219N | A98G, V108I | K20R, V21I, V35I, K43E, E44A, V118I, K122P, D123E, I142V, T165I, D177E, H208Y, R211K, K223E, L228H, A272P, K277R, I293V, E297R, A360T |
| >2014-30512| codons 1-399 PISPIETVPVKLKPGMDGPRIKQWPLTEEKIKALIEICTELEEAGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTILDVGDAYFSIPL DPEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMIKILEPFRKQNPEIVI YQYVDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTPDNKHQEEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGT HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |