Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2012 | 2012-30930 | Netherlands | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82T, I84V | K43T | L10I, K20R, E35D, M36V, N37T, R57K, L63P, I64V, H69Y, A71V, V77I, I85V, I93L |
| >2012-30930| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDVTLPGRWTPKIIGGIGGFVKVKQYD QIPVEICGYKVIGTVLIGPTPTNVVGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, T215F | K219Q | K101E, G190A | V35M, K64KR, K104R, T107A, K122P, S162C, P170PS, Q174QR, V179I, I195K, G196E, T200A, H208Y, R211K, A272P, K277KR, I293V, E297K, I329V, G359S, K366R, E370D, A371V, I382T, K385R, K390R |
| >2012-30930| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEKEGKISKIGPENPYNTPV FAIRKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLEKKRSVAVLDVGDAYFSVPL DPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILESFRKRNPDIII YQYMDDLYVASDLEKEQHRAKIEELRQYLLKWGFFTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVRQLTDVVQKIATESIVTWGRTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |