<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-2012 2012-30930 Netherlands 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82T, I84V K43T L10I, K20R, E35D, M36V, N37T, R57K, L63P, I64V, H69Y, A71V, V77I, I85V, I93L  
>2012-30930| codons 1-99
PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDVTLPGRWTPKIIGGIGGFVKVKQYD
QIPVEICGYKVIGTVLIGPTPTNVVGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74I, T215F K219Q K101E, G190A   V35M, K64KR, K104R, T107A, K122P, S162C, P170PS, Q174QR, V179I, I195K, G196E, T200A, H208Y, R211K, A272P, K277KR, I293V, E297K, I329V, G359S, K366R, E370D, A371V, I382T, K385R, K390R  
>2012-30930| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEKEGKISKIGPENPYNTPV
FAIRKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLEKKRSVAVLDVGDAYFSVPL
DPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILESFRKRNPDIII
YQYMDDLYVASDLEKEQHRAKIEELRQYLLKWGFFTPDQKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEVQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVRQLTDVVQKIATESIVTWGRTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006