Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2011 | 2011-30925 | Netherlands | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74LV, M184V, L210W, T215Y | K219KR, N348I | L100I, K103KN | K20R, V35L, T39A, E44D, V60VI, A98S, V118I, M164ML, G196E, Q197H, E203K, H208Y, R211D, K223KE, L228H, K277R, T286A, E297R, Q334Y, M357MT, G359GS, A371AT, I375V |
| >2011-30925| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICAELEKDGKISKIGPENPYNTPI FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPSGIKKNKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSLTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEHHRTKIKELRQYLWDWGFYTPDRKHQEEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEVIPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGYGQWTYQIYQEPFKILKTGKYARTRSA HTNDVKQLTETVQKVATESIVIWGKTPKFKLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, I84V | L10F, L24I, L33F, G73C | E34Q, I62V, L63P, P79A, I93L |
| >2011-30925| codons 1-99 PQITLWQRPFVTIKIGGQLKEALIDTGADDTVFQEMNLPGRWKPKLIGGIGGFVKVRQYD QVPIEICGHKAICTVLVGATPVNVIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |