<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-2011 2011-30925 Netherlands 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L74LV, M184V, L210W, T215Y K219KR, N348I L100I, K103KN   K20R, V35L, T39A, E44D, V60VI, A98S, V118I, M164ML, G196E, Q197H, E203K, H208Y, R211D, K223KE, L228H, K277R, T286A, E297R, Q334Y, M357MT, G359GS, A371AT, I375V  
>2011-30925| codons 1-400
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICAELEKDGKISKIGPENPYNTPI
FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPSGIKKNKSVTVLDVGDAYFSIPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSLTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIEHHRTKIKELRQYLWDWGFYTPDRKHQEEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEVIPLTREAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGYGQWTYQIYQEPFKILKTGKYARTRSA
HTNDVKQLTETVQKVATESIVIWGKTPKFKLPIQKETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, I84V L10F, L24I, L33F, G73C E34Q, I62V, L63P, P79A, I93L  
>2011-30925| codons 1-99
PQITLWQRPFVTIKIGGQLKEALIDTGADDTVFQEMNLPGRWKPKLIGGIGGFVKVRQYD
QVPIEICGHKAICTVLVGATPVNVIGRNLLTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006