Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2007 | 2007-30423 | Netherlands | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, V82A, L90M | L33F, K43T, F53FL | L10I, K20R, E35D, M36I, K55R, R57K, D60E, I62V, L63P, K70T, A71V, I72V, I93L |
| >2007-30423| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVFEDINLPGRWTPKIVGGIGGLVRVKQYE QVPIEICGHTVVGTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75M, L210W, T215Y | N348I | Y188L | S3C, T39E, V60I, K122E, I135V, I167V, V179I, I202V, H208Y, R211K, V245M, A272P, K277R, I293V, I326V, I329V, Q334E, M357T, T386I, K390KR |
| >2007-30423| codons 1-399 PICPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICEELEKEGKISKIGPENPYNTPI FAIKKKNSDKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKVLEPFRKQNPDIII YQYMDDLLVGSDLEIGQHRTKVEELRQYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLVAEVQKQGEGQWTYQIYQEPFKILKTGKYARTRGA HTNDVKQLTEAVQKIATESIVIWGKIPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |