Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2006 | 2006-30423 | Netherlands | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K219N | L100I, K103N | P9PS, K20R, E44D, V118I, K122E, D123E, I135T, I202V, R211K, V245VE, L283I, I293V, P294T, E297K, I326M, I329V, Q334E, R356K, G359S, A371V, S379C, T386V, K390R |
| >2006-30423| codons 1-400 PISPIETVSVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKVEELRQHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLIRGTKALTEVVTLTKEAE LELAENREILKEPVHGVYYDPSKDLMAEVQKQGEGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLTEVVQKIATECIVIWGKVPKFRLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48GV, I54V, V82S, I84IV | L10I, T12TI, I13V, I15IV, G16E, K20M, M36I, I62V, L63N, I64V, I72V, T74AS |
| >2006-30423| codons 1-99 PQITLWQRPIVIVKVEGQLMEALLDTGADDTVLEEINLPGRWKPKLIVGIGGFVKVRQYD QVNVEICGHKAVGSVLVGPTPSNVIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |