<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-2006 2006-30423 Netherlands 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, L210W, T215Y K219N L100I, K103N   P9PS, K20R, E44D, V118I, K122E, D123E, I135T, I202V, R211K, V245VE, L283I, I293V, P294T, E297K, I326M, I329V, Q334E, R356K, G359S, A371V, S379C, T386V, K390R  
>2006-30423| codons 1-400
PISPIETVSVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL
DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKVEELRQHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLIRGTKALTEVVTLTKEAE
LELAENREILKEPVHGVYYDPSKDLMAEVQKQGEGQWTYQIYQEPFKNLKTGKYAKMRSA
HTNDVKQLTEVVQKIATECIVIWGKVPKFRLPIQKETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, G48GV, I54V, V82S, I84IV   L10I, T12TI, I13V, I15IV, G16E, K20M, M36I, I62V, L63N, I64V, I72V, T74AS  
>2006-30423| codons 1-99
PQITLWQRPIVIVKVEGQLMEALLDTGADDTVLEEINLPGRWKPKLIVGIGGFVKVRQYD
QVNVEICGHKAVGSVLVGPTPSNVIGRNLLTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006