Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2005 | 2005-30423 | Netherlands | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54V, V82A, L90M | N37D, D60E, I62V, L63P, A71V, I93L |
| >2005-30423| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKLIVGIGGFVKVRQYE QVPIEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, M184V, T215Y | K219Q | A98AG | T39TA, K43Q, K101Q, D123E, I180V, Q207E, H208Y, R211K, D218E, L228LHR, V245VIM, A272P, K277R, V292VI, I293IV, E297AITV, I329V, G333E, Q334Y, R356K, K366KR | E29EK, W229WG |
| >2005-30423| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEKKIKALVEICAELEQEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPGGLQKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVV YQYVDDLYVGSDLEIGQHRTKIEELREYLLKWGFYTPEQKHQKEPPFRGMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEIVPLTVEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQEYGQWTYQIYQEPFKNLKTGKYAKMRGA HTNDVRQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |