Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2003 | 2003-30422 | Netherlands | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75M, M184V, L210W, T215Y | K219Q | Y188L | V35M, K43KE, V60I, K102M, V118I, K122E, I135V, D177G, H208Y, R211K, D218E, L228H, A272P, I293V, E297K, G333E, Q334P, R356K, G359S, A371V, T377M |
| >2003-30422| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEEEGKISKIGPENPYNTPI FAIKKKNSTRWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKMKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPGIVI YQYVDDLLVGSDLEIGQHRTKIEELRQYLWKWGFYTPEQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQEPGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLTEVVQKIAMESIVIWGKTPKFKLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, L33F, G73S | T4TS, G16GA, L63P, A71V, I72F, V77I, I85V, T91S |
| >2003-30422| codons 1-99 PQISLWQRPFVTIKIAGQLKEALLDTGADDTVFEEMNLPGRWKPKIIGGIGGFVKVRQYD QIPIEICGHKVFSTVLIGPTPVNVVGRNLMSQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |