Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-2001 | 2001-30416 | Netherlands | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, L210W, T215Y | K219N | L100I, K103N | E44D, V118I, K122E, I135T, Q174R, G196E, T200M, E203D, R211K, A272P, V276I, L283I, I293V, P294T, S322T, I326V, R356K, M357A, G359S, A371V, E399EDG |
| >2001-30416| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDIVI YQYMDDLYVGSDLEIEQHRMKIDELRQHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKIKQLCKLIRGTKALTEVVTLTEEAE LELAENREILKEPVHGVYYDPTKDLVAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKARSA HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWGA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82F, L90M | Q58E | L10I, I13IV, K20R, E35D, M36I, I62V, L63P, I64V, A71V, V77VI, I93L, C95L |
| >2001-30416| codons 1-99 PQITLWQRPIVTVKIGGQLREALLDTGADDTVLEDINLPGRWKPKMIGGIGGFVKVREYD QVPVEICGHKVIGTVLIGPTPFNIIGRNLMTQLGLTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |