Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1606 | 1606-30929 | Ireland | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T74TP | E35D, M36I, N37D, K43R, R57RK, L63P, H69K, A71AT, I93L |
| >1606-30929| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDIDLPGRWRPKMIGGIGGFIKVKQYD QIPIEICGKKTIGPVLVGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184MV, T215F | Y181YC | V118I, D123E, I135IM, D177DE, I178M, Q207E, R211K, H221HY, A272P, K281KR, E297K, K311KR, V317A, I326V, Q334L, M357T, A376AT |
| >1606-30929| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI CQYVDDLYVGSDLEIGQHRTKIEELREHLLKWGFFTPDKKYQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVIPLTKEAE LELAENREILREPVHGAYYDPSKDLVAEIQKQGLGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |