Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1603 | 1603-30923 | Ireland | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, V82A, L90M | G73S | L10I, K45R, L63P, I64V, I72L, V77I, I93L, C95F |
| >1603-30923| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPRIIGGIGGFIKVRQYD QIPVEICGHKALSTVLIGPTPANIIGRNLMTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, L210W, T215Y | K219E | K20R, K22R, K43N, I50IV, A98S, V118I, K122KE, K173Q, T200E, I202IV, H208Y, R211K, V245M, I293IV, E312Q, S322SA, M357MT, R358K, K390R |
| >1603-30923| codons 1-400 PISPIETVPVKLKPGMDGPRVRQWPLTEEKIKALVEICTELENEGKISKVGPENPYNTPV FAIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRQQNPDIVI YQYMDDLYVGSDLEIGQHREKVEELRQYLWKWGFYTPDEKHQKEPPFLWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKQPVHGVYYDPAKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTKGA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |