<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1439 1439-30929 Denmark 2003 HIV1 D Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, L210W, T215Y   L100I, K103N A98G V35T, T39K, K43E, E44D, K49R, V60I, K122E, Q174K, D177E, I178M, Q207E, R211K, V245Q, D250E, A272P, L282C, L283I, R284K, T286S, I293V, E297A, G335D, P345Q, F346Y, K347KR, R356K, A360T, T377Q, S379C, K390R  
>1439-30929| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICKELEEDGKISRIGPENPYNTPI
FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPGGIKKNKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPEMVI
YQYMDDLYVGSDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKCIKGSKALTEVVPLTAEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEQYRNLKTGKYAKMRGT
HTNDVKQLTEAVQKIAQECIVIWGKTPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, L76LV, V82A, L90M L10FI I13V, K20I, E34EK, M36I, R41K, I62V, L63P, I64IV, A71T, L89LI, I93L  
>1439-30929| codons 1-99
PQITLWQRPIVTVKIGGQLIEALLDTGADDTVLKEINLPGKWKPKIIGGIGGFVKVRQYD
QVPVEICGHKTIGTVVVGPTPANIIGRNIMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006