Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1435 | 1435-30318 | Denmark | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K219Q | Y181C | E6D, K20R, T39A, K43N, E44D, V118I, K122KE, Q174N, T200A, I202V, E203K, Q207E, H208Y, R211K, D218E, A272P, T286A, V317A, Q334I, M357T, G359S, T369V, A376S, T386I |
| >1435-30318| codons 1-400 PISPIDTVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELENDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKNNPDIVI CQYMDDLYVGSDLEIGQHRAKVKELREYLWKWGFYTPEQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTEEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGIGQWTYQIYQEPFKNLKTGKYARTRSA HTNDVKQLVEAVQKISTESIVIWGKIPKFKLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | G73S | L10I, I15V, G16A, L19I, K20R, L24F, E35ED, M36I, R41K, I62V, L63P, A71V, I93L |
| >1435-30318| codons 1-99 PQITLWQRPIVTIKVAGQIREALFDTGADDTVLEDINLPGKWKPKLIGGIGGFVKVRQYD QVPIEICGHKVISTVLVGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |