<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1435 1435-30318 Denmark 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A, L90M G73S L10I, I15V, G16A, L19I, K20R, L24F, E35ED, M36I, R41K, I62V, L63P, A71V, I93L  
>1435-30318| codons 1-99
PQITLWQRPIVTIKVAGQIREALFDTGADDTVLEDINLPGKWKPKLIGGIGGFVKVRQYD
QVPIEICGHKVISTVLVGPTPANIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, L210W, T215Y K219Q Y181C   E6D, K20R, T39A, K43N, E44D, V118I, K122KE, Q174N, T200A, I202V, E203K, Q207E, H208Y, R211K, D218E, A272P, T286A, V317A, Q334I, M357T, G359S, T369V, A376S, T386I  
>1435-30318| codons 1-400
PISPIDTVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELENDGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKNNPDIVI
CQYMDDLYVGSDLEIGQHRAKVKELREYLWKWGFYTPEQKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTEEAE
LELAENREILKEPVHGAYYDPSKDLIAEIQKQGIGQWTYQIYQEPFKNLKTGKYARTRSA
HTNDVKQLVEAVQKISTESIVIWGKIPKFKLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006