<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1433 1433-30220 Denmark 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, K70G, L74I, T215Y D67S, V75T, K219R K101E, Y181C V108I, E138K E6N, K20R, V35M, T39AS, S68G, V90VI, A98S, K122E, I135T, Q207E, D218DE, H221Y, L228R, V245KN, A272S, T286A, I293V, E297K, I329V, A371AV  
>1433-30220| codons 1-400
PISPINTVPVKLKPGMDGPRVKQWPLTEEKIKALMEICSELEKEGKISKIGPENPYNTPV
FAIKKKSGTGWRKITDFRELNKRTQDFWEIQLGIPHPSGLEKKKSVTILDVGDAYFSVPL
DEDFRKYTAFTIPSTNNKTPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
CQYMDDLYVGSDLEIGQHRTKIEELREHLLRWGFYTPERKYQKEPPFRWMGYELHPDKWT
VQPINLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGAKALTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEVQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M Q58E, N83D L10I, T12N, I13A, K14KI, L19M, K20R, A22V, M36I, R41RK, K55R, R57K, I62V, L63P, I64V, I66V, H69R, T74S, Q92K, I93L, C95F  
>1433-30220| codons 1-99
PQITLWQRPIVNAIIGGQMREVLLDTGADDTVLEEINLPGKWKPKIIGGIGGFVRVKEYD
QVPVEVCGRKAIGSVLVGPTPVDVIGRNLMTKLGFTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006