Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1433 | 1433-30220 | Denmark | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | Q58E, N83D | L10I, T12N, I13A, K14KI, L19M, K20R, A22V, M36I, R41RK, K55R, R57K, I62V, L63P, I64V, I66V, H69R, T74S, Q92K, I93L, C95F |
| >1433-30220| codons 1-99 PQITLWQRPIVNAIIGGQMREVLLDTGADDTVLEEINLPGKWKPKIIGGIGGFVRVKEYD QVPVEVCGRKAIGSVLVGPTPVDVIGRNLMTKLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70G, L74I, V75T, T215Y | D67S, K219R | K101E, Y181C | V108I, E138K | E6N, K20R, V35M, T39AS, S68G, V90VI, A98S, K122E, I135T, Q207E, D218DE, H221Y, L228R, V245KN, A272S, T286A, I293V, E297K, I329V, A371AV |
| >1433-30220| codons 1-400 PISPINTVPVKLKPGMDGPRVKQWPLTEEKIKALMEICSELEKEGKISKIGPENPYNTPV FAIKKKSGTGWRKITDFRELNKRTQDFWEIQLGIPHPSGLEKKKSVTILDVGDAYFSVPL DEDFRKYTAFTIPSTNNKTPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVGSDLEIGQHRTKIEELREHLLRWGFYTPERKYQKEPPFRWMGYELHPDKWT VQPINLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGAKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |