<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1432 1432-30818 Denmark 2003 HIV1 D Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, L76V, V82T L24I L10I, I13A, K20I, E35D, M36I, R41K, Q61H, L63P, H69K, T74S, L89I  
>1432-30818| codons 1-99
PQITLWQRPIVTAKIGGQLIEALIDTGADDTVLEDINLPGKWKPKIIGGIGGFVKVRQYD
HIPIEICGKKAIGSVVVGPTPTNIIGRNILTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70R, M184V K219H K103N K238T P14LS, V35T, T39A, K43E, V60I, F87FL, D121Y, K122E, D123E, D177E, I178M, T200R, E203K, Q207DE, R211K, V245R, D250E, A272P, K275R, Q278H, L282C, T286A, I293V, E297K, G335D, P345Q, F346Y, R356K, M357S, A360T, A371V, I375V, T377H, S379C, K390R  
>1432-30818| codons 1-399
PISPIETVPVKLKSGMDGPKVKQWPLTEEKIKALTEICAEMEEEGKISKIGPENPYNTPI
FAIKKKNSTRWRKLVDFRELNKRTQDLWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
YEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI
YQYVDDLYVGSDLEIGQHRRKIKELREHLLKWGFTTPDHKHQKEPPFLWMGYELHPDTWT
VQPIRLPEKESWTVNDIQKLVGKLNWASQIYPGIRVKHLCKCLRGAKALTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEQYKNLKTGKYAKSRGT
HTNDVKQLTEVVQKVAHECIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006