Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1432 | 1432-30818 | Denmark | 2003 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82T | L24I | L10I, I13A, K20I, E35D, M36I, R41K, Q61H, L63P, H69K, T74S, L89I |
| >1432-30818| codons 1-99 PQITLWQRPIVTAKIGGQLIEALIDTGADDTVLEDINLPGKWKPKIIGGIGGFVKVRQYD HIPIEICGKKAIGSVVVGPTPTNIIGRNILTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V | K219H | K103N | K238T | P14LS, V35T, T39A, K43E, V60I, F87FL, D121Y, K122E, D123E, D177E, I178M, T200R, E203K, Q207DE, R211K, V245R, D250E, A272P, K275R, Q278H, L282C, T286A, I293V, E297K, G335D, P345Q, F346Y, R356K, M357S, A360T, A371V, I375V, T377H, S379C, K390R |
| >1432-30818| codons 1-399 PISPIETVPVKLKSGMDGPKVKQWPLTEEKIKALTEICAEMEEEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDLWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL YEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI YQYVDDLYVGSDLEIGQHRRKIKELREHLLKWGFTTPDHKHQKEPPFLWMGYELHPDTWT VQPIRLPEKESWTVNDIQKLVGKLNWASQIYPGIRVKHLCKCLRGAKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEQYKNLKTGKYAKSRGT HTNDVKQLTEVVQKVAHECIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |