<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1430 1430-30429 Denmark 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, G48V, I54V, V82A, I84V, L90M L33F, Q58E, G73S L10I, I13V, E34Q, I62V, L63P, A71V, I72V, V77I, I93L  
>1430-30429| codons 1-99
PQITLWQRPIVTVKIGGQLKEALLDTGADDTVFQEMNLPGRWKPKLIVGIGGFVKVREYD
QVPIEICGHKVVSTVLIGPTPANVIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L210W, T215Y V75L K101KE, V106A, G190A F227L V35I, T39A, K43Q, E44D, K66KR, V118I, D123E, I135T, D177E, G196E, E203K, Q207E, H208Y, R211Q, K223Q, V245E, T286A, A288S, E297R, V317A, I329V, Q334L, K350R, M357T, G359S, K366R, A371V, K390R, Q394H  
>1430-30429| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEQDGKISKIGPENPYNTPV
FAIKKRNSTKWRKLLDFRELNKRTQDFWEVQLGIPHPAGLEKKKSATVLDVGDAYFSIPL
DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI
YQYMDDLYVASDLEIEQHRTKIKELREYLWQWGFYTPDKKHQQEPPLLWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKSLTEVIPLTREAE
LELAENREILKEPVHGAYYDPSKDLIAEVQKQGLGQWTYQIYQEPFKNLRTGKYARTRSA
HTNDVRQLTEVVQKIATESIVIWGKTPKFRLPIHKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006