Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1430 | 1430-30429 | Denmark | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54V, V82A, I84V, L90M | L33F, Q58E, G73S | L10I, I13V, E34Q, I62V, L63P, A71V, I72V, V77I, I93L |
| >1430-30429| codons 1-99 PQITLWQRPIVTVKIGGQLKEALLDTGADDTVFQEMNLPGRWKPKLIVGIGGFVKVREYD QVPIEICGHKVVSTVLIGPTPANVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | V75L | K101KE, V106A, G190A | F227L | V35I, T39A, K43Q, E44D, K66KR, V118I, D123E, I135T, D177E, G196E, E203K, Q207E, H208Y, R211Q, K223Q, V245E, T286A, A288S, E297R, V317A, I329V, Q334L, K350R, M357T, G359S, K366R, A371V, K390R, Q394H |
| >1430-30429| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEQDGKISKIGPENPYNTPV FAIKKRNSTKWRKLLDFRELNKRTQDFWEVQLGIPHPAGLEKKKSATVLDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYMDDLYVASDLEIEQHRTKIKELREYLWQWGFYTPDKKHQQEPPLLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKSLTEVIPLTREAE LELAENREILKEPVHGAYYDPSKDLIAEVQKQGLGQWTYQIYQEPFKNLRTGKYARTRSA HTNDVRQLTEVVQKIATESIVIWGKTPKFRLPIHKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |