Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1429 | 1429-30424 | Denmark | 2003 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, T215F | K219Q | G190A | T7P, K20R, K22R, V35T, T39S, V60I, D121Y, K122E, I135T, I178M, V179I, G196E, T200R, Q207E, R211K, D218E, V245K, D250E, A272P, Q278H, L282C, T286A, I293V, E297R, G335D, P345Q, F346Y, N348P, R356K, M357T, A360T, T377R, K390R, E399D |
| >1429-30424| codons 1-399 PISPIEPVPVKLKPGMDGPRVRQWPLTEEKIKALTEICSELEKEGKISKIGPENPYNTPI FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMII YQYVDDLYVASDLEIEQHRRKIEELREHLLKWGFFTPEQKHQKEPPFLWMGYELHPDKWT VQPIKLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKHLCKCLRGAKALTEVVPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEQYKPLKTGKYAKTRGT HTNDVKQLTEAVQKIARESIVIWGKTPKFRLPIQKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82T | L24I | L10I, I13V, E35D, M36I, N37S, R41K, K55R, L63P, I64V, A71V, I72V, V77I, I93L |
| >1429-30424| codons 1-99 PQITLWQRPIVTVKIGGQLKEALIDTGADDTVLEDISLPGKWKPKIIGGIGGFVRVRQYD QIPVEICGHKVVGTVLIGPTPTNIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |