Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1428 | 1428-30624 | Denmark | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82S | L10F, L24I, L33LF, F53FL | L19I, K20R, E35D, M36I, N37D, R41KN, K55R, R57K, I62IV, L63P, A71V, I72V, T74TS, L89LI |
| >1428-30624| codons 1-99 PQITLWQRPFVTIKIGGQIREALIDTGADDTVFEDIDLPGNWKPKIIGGIGGLVRVKQYD QVPIEICGHKVVGSVLVGPTPSNIIGRNILTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75M, M184V, L210LW, T215F | K219Q | K103N, G190A | V108VI | P4Q, E6K, V8VI, T39A, E44D, E53D, V60I, K102N, K122E, T139M, I142V, S162Y, T200A, E203ED, R211NS, D218DE, L228LR, R284K, A288S, E297K, K311R, D324E, I329L, R358K, G359GS, S379SC |
| >1428-30624| codons 1-399 PISQIKTIPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKDGKISKIGPDNPYNTPI FAIKKKNSTRWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKNNKSVTILDVGDAYFSVPL DEDFRKYTAFTIPSINNEMPGVRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI YQYVDDLYVASDLEIGQHRAKIDELRQHLWSWGFFTPEQKHQKEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGTKSLTEVIPLTKEAE LELAENREILREPVHGVYYDPSKELIAELQKQGQGQWTYQIYQEPFKNLKTGKYARMKSA HTNDVKQLTEAVQKIATECIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |