<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1427 1427-30623 Denmark 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184V, L210W, T215Y   K101E, Y181CF, G190S A98G, V179VF E28EK, V35M, T39A, K43E, E44D, K102R, V118I, K122E, G196E, Q207K, R211D, L228LH, A272S, I293V, P313K, D324E, Y342F, M357T, A360T, K366R, K390R, K395R, E399D  
>1427-30623| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTKEKIKALMEICAELEEDGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLERKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIFI
FQYVDDLYVSSDLEIEQHRTKIEELRKHLWDWGFYTPDKKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGTKALTEVVPLTEEAE
LELAENREILKEKVHGVYYDPSKELIAEIQKQGQGQWTYQIFQEPFKNLKTGKYARTRGT
HTNDVRQLTEAVQKIATESIVIWGKTPKFRLPIQRETWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54A, V82A, L90M L33F, K43T T4P, L10I, I15V, Q18H, K20R, E34Q, E35D, M36I, R57K, I62V, L63P, A71I, I85V, I93L  
>1427-30623| codons 1-99
PQIPLWQRPIVTIKVGGHLREALLDTGADDTVFQDINLPGRWTPKIIGGIGGFAKVKQYD
QVPIEICGHKIIGTVLVGPTPANIVGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006