Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1427 | 1427-30623 | Denmark | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54A, V82A, L90M | L33F, K43T | T4P, L10I, I15V, Q18H, K20R, E34Q, E35D, M36I, R57K, I62V, L63P, A71I, I85V, I93L |
| >1427-30623| codons 1-99 PQIPLWQRPIVTIKVGGHLREALLDTGADDTVFQDINLPGRWTPKIIGGIGGFAKVKQYD QVPIEICGHKIIGTVLVGPTPANIVGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K101E, Y181CF, G190S | A98G, V179VF | E28EK, V35M, T39A, K43E, E44D, K102R, V118I, K122E, G196E, Q207K, R211D, L228LH, A272S, I293V, P313K, D324E, Y342F, M357T, A360T, K366R, K390R, K395R, E399D |
| >1427-30623| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIKALMEICAELEEDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLERKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIFI FQYVDDLYVSSDLEIEQHRTKIEELRKHLWDWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEKVHGVYYDPSKELIAEIQKQGQGQWTYQIFQEPFKNLKTGKYARTRGT HTNDVRQLTEAVQKIATESIVIWGKTPKFRLPIQRETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |