Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1426 | 1426-30225 | Denmark | 2003 | HIV1 | CRF01_AE | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54A, V82A | T4TS, L10I, V11L, I13V, K14R, I15V, K20I, E35D, M36I, R41K, H69K, K70R, L89I |
| >1426-30225| codons 1-99 PQISLWQRPILTVRVGGQLIEALLDTGADDTVLEDINLPGKWKPKMIVGIGGFAKVRQYD QILIEICGKRAIGTVLVGPTPANIIGRNILTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | P4S, E6D, E28A, V35I, T39K, K43E, E44D, K102KR, V118I, K122E, D123S, I135T, S162C, K173T, Q174K, Q207A, R211N, D218DE, V245E, E291D, I293V, E312T, I329V, G335D, K350R, M357S, G359S, T369A, A371V, K395R, E399D |
| >1426-30225| codons 1-399 PISSIDTVPVKLKPGMDGPKVKQWPLTAEKIKALIEICKELEEDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSVTVLDVGDAYFSIPL DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRTKNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRAHLWNWGFYTPEKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTDVVPLTEEAE LELAENREILKTPVHGVYYDPSKDLIAEVQKQGQDQWTYQIYQEPFKNLRTGKYARSRSA HTNDVKQLAEVVQKIATESIVIWGKTPKFKLPIQRETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |