<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1426 1426-30225 Denmark 2003 HIV1 CRF01_AE Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I54A, V82A   T4TS, L10I, V11L, I13V, K14R, I15V, K20I, E35D, M36I, R41K, H69K, K70R, L89I  
>1426-30225| codons 1-99
PQISLWQRPILTVRVGGQLIEALLDTGADDTVLEDINLPGKWKPKMIVGIGGFAKVRQYD
QILIEICGKRAIGTVLVGPTPANIIGRNILTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L210W, T215Y       P4S, E6D, E28A, V35I, T39K, K43E, E44D, K102KR, V118I, K122E, D123S, I135T, S162C, K173T, Q174K, Q207A, R211N, D218DE, V245E, E291D, I293V, E312T, I329V, G335D, K350R, M357S, G359S, T369A, A371V, K395R, E399D  
>1426-30225| codons 1-399
PISSIDTVPVKLKPGMDGPKVKQWPLTAEKIKALIEICKELEEDGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSVTVLDVGDAYFSIPL
DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRTKNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRAHLWNWGFYTPEKKHQKEPPFLWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTDVVPLTEEAE
LELAENREILKTPVHGVYYDPSKDLIAEVQKQGQDQWTYQIYQEPFKNLRTGKYARSRSA
HTNDVKQLAEVVQKIATESIVIWGKTPKFKLPIQRETWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006