Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1425 | 1425-30224 | Denmark | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70KR, L74I, M184I, L210W, T215Y | K219E | K103N, Y181C | V35T, K43E, E44A, V118I, K122E, I135T, V179I, I202V, Q207R, R211K, D218E, L228R, A272P, K277R, I293V, E297K, Q334L, R356K, K366R, T369V, I375V, K388R, E399D |
| >1425-30224| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEEAGKISKIGPENPYNTPV FAIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII CQYIDDLYVGSDLEIGQHRTKVEELRRHLWKWGFYTPEEKHQKEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKNLKTGKYAKMRGA HTNDVRQLVEAVQKVATESIVIWGKTPRFKLPIQKETWDA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48M, I54A, V82A | L24I | L10I, L63P, A71V, I72IT, T74S, V77I, I93L |
| >1425-30224| codons 1-99 PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLEEMNLPGRWKPKLIMGIGGFAKVRQYD QIPIEICGHKVTGSVLIGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |