Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1423 | 1423-30311 | Denmark | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, M184V, T215F | A62AV, D67GS, K219Q | G190A | K20R, K46Q, S68SG, T69N, K122E, V179VI, T200D, E203K, R211K, D218E, V261I, K277R, I293V, V317T, M357MI, R358K, D364DE, T386TI, K390R |
| >1423-30311| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGQISKIGPENPYNTPV FVIKKKSGNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYVDDLYVASDLEIGQHRDKIKELRQHLLKWGFFTPEQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLIGKLNWASQIYAGIKVRQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGTYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARIKGA HTNEVKQLTEAVQKIATESIVIWGKIPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82T, I84V, L90M | L10FI, L33F, G73S | L19LIM, E34Q, R57RK, Q61QH, I62IV, L63P, A71V, I72T, P79D |
| >1423-30311| codons 1-99 PQITLWQRPIVTIKIGGQMKEALLDTGADDTVFQEMNLPGRWKPKMIGGIGGFVKVKQYD HVPIEICGHKVTSTVLVGDTPTNVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |