<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1423 1423-30311 Denmark 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82T, I84V, L90M L10FI, L33F, G73S L19LIM, E34Q, R57RK, Q61QH, I62IV, L63P, A71V, I72T, P79D  
>1423-30311| codons 1-99
PQITLWQRPIVTIKIGGQMKEALLDTGADDTVFQEMNLPGRWKPKMIGGIGGFVKVKQYD
HVPIEICGHKVTSTVLVGDTPTNVIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K70R, M184V, T215F A62AV, D67GS, K219Q G190A   K20R, K46Q, S68SG, T69N, K122E, V179VI, T200D, E203K, R211K, D218E, V261I, K277R, I293V, V317T, M357MI, R358K, D364DE, T386TI, K390R  
>1423-30311| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGQISKIGPENPYNTPV
FVIKKKSGNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII
YQYVDDLYVASDLEIGQHRDKIKELRQHLLKWGFFTPEQKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLIGKLNWASQIYAGIKVRQLCKLLRGTKALTEVVPLTEEAE
LELAENREILKEPVHGTYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARIKGA
HTNEVKQLTEAVQKIATESIVIWGKIPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006