<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1422 1422-30311 Denmark 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82A, I84V, L90M L33F, Q58E, T74P L10I, T12I, I13V, K20R, E34Q, E35D, M36I, N37T, R41K, R57K, I62V, L63P, A71V, I72V, I93L  
>1422-30311| codons 1-99
PQITLWQRPIVIVKIGGQLREALLDTGADDTVFQDITLPGKWKPKMIGGIGGFVKVKEYD
QVPIEICGHKVVGPVLVGPTPANVIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, L74V, M184V, T215F K219Q K101E, Y188L   E6K, K32N, V35I, K122E, I135K, S162Y, T200A, E203D, Q207E, E248D, T286A, E297K, E312A, S322T, D324E, G333E, K350KR, R356K, G359S, A371IV, T377M, K390R  
>1422-30311| codons 1-400
PISPIKTVPVKLKPGMDGPKVKQWPLTEEKINALIEICTEMEKEGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSKNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI
YQYVDDLLVGSDLEIGQHRAKIDELREHLLRWGFFTPDQKHQKEPPFLWMGYELHPDKWT
VQPIVLPDKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTKEAE
LELAENREILKAPVHGVYYDPTKELIAEIQKQEQGQWTYQIYQEPFKNLRTGKYAKMRSA
HTNDVKQLTEVVQKIAMESIVIWGKTPKFRLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006