Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1422 | 1422-30311 | Denmark | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, I84V, L90M | L33F, Q58E, T74P | L10I, T12I, I13V, K20R, E34Q, E35D, M36I, N37T, R41K, R57K, I62V, L63P, A71V, I72V, I93L |
| >1422-30311| codons 1-99 PQITLWQRPIVIVKIGGQLREALLDTGADDTVFQDITLPGKWKPKMIGGIGGFVKVKEYD QVPIEICGHKVVGPVLVGPTPANVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, L74V, M184V, T215F | K219Q | K101E, Y188L | E6K, K32N, V35I, K122E, I135K, S162Y, T200A, E203D, Q207E, E248D, T286A, E297K, E312A, S322T, D324E, G333E, K350KR, R356K, G359S, A371IV, T377M, K390R |
| >1422-30311| codons 1-400 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKINALIEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSKNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI YQYVDDLLVGSDLEIGQHRAKIDELREHLLRWGFFTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPDKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTKEAE LELAENREILKAPVHGVYYDPTKELIAEIQKQEQGQWTYQIYQEPFKNLRTGKYAKMRSA HTNDVKQLTEVVQKIAMESIVIWGKTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |