Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1421 | 1421-30304 | Denmark | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48A, I54V, V82A, L90M | K43T | L10I, K20R, E35D, M36I, N37D, L63P, A71I, I93L |
| >1421-30304| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDIDLPGRWTPKMIAGIGGFVKVRQYD QIPIEICGHKIIGTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | K103N | S3SC, P4PT, V35R, T39A, K43Q, S68SG, K101KQ, I135V, I142V, G196E, E203D, R211A, L228LH, V245K, I293V, E297EK, L325I, I326V, Q334X, G359S, K366KR, T369TA, A371V, A400AT |
| >1421-30304| codons 1-400 PICTIETVPVKLKPGMDGPKVKQWPLTEEKIKALREICAELEQEGKISKIGPENPYNTPV FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIDELRQHLWAWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDIVAEIQKQGXGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVRQLAEVVQKIATESIVIWGKTPKFKLPIQKETWET |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |