Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1414 | 1414-30326 | Denmark | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69DN, K70R, M184V, T215F | K219Q, N348I | K20R, D121Y, K122E, I135T, S162C, D177E, V179I, G196E, T200A, E203D, R211K, L228H, Q242H, A272P, A288T, E291ED, A360AT, A376V, K390R |
| >1414-30326| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPEIII YQYVDDLYVGSDLEIEQHRAKIDELRQHLLKWGFFTPDQKHQKEPPFHWMGYELHPDKWT VHPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKTLTDVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKILKTGKYARMRGT HTNDVKQLTEAVQKIVTESIVIWGKTPKFRLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82IM, L90M | G73GC | L10I, T12K, L19T, K20I, E35D, M36I, R41RK, I62V, L63P, H69Q, T74S |
| >1414-30326| codons 1-99 PQITLWQRPIVKIKIGGQTIEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFVKVRQYD QVPIEICGQKAICSVLVGPTPMNIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |