Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1413 | 1413-30326 | Denmark | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | L10F, L33F | G16A, K43S, I62V, L63P, H69R, A71T, I72V, I93L, C95F |
| >1413-30326| codons 1-99 PQITLWQRPFVTIKIAGQLKEALLDTGADDTVFEEMNLPGRWSPKIIGGIGGFVKVRQYD QVPIEICGRKTVGTVLVGPTPANIIGRNLMTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, V75M, M184V, L210W, T215Y | K219KN, N348I | L100I, K103N | S3SC, E6D, K20KR, V35VI, E40X, K43N, E44ED, A98S, V111VIM, K122E, T200A, E203EV, Q207E, L228R, A272P, K277R, E297Q, Q334L, G359S, K390KR |
| >1413-30326| codons 1-399 PICPIDTVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTXLENDGKISKIGPENPYNTPV FAIKKKDSTKWRKVMDFRELNKRTQDFWEVQLGIPHPSGIKKNKSVTVLDMGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIVELREHLWRWGFYTPDNKHQKEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTQEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKILKTGKYARMRSA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |