<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1412 1412-30312 Denmark 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
T69T_T, K70R, L74V K219Q, N348I Y181C V108I V35R, T39A, K49KR, V60I, K64N, S68T, V118I, I135T, K166KQ, Q174K, I180IV, I202V, E203K, Q207E, R211K, F214L, H221Y, K223R, F227FY, A272P, R284K, I293V, V317A, A327V, T338S, M357T, G359S, K366R, E399D  
>1412-30312| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALREICAEMEKEGKISRIGPENPYNTPI
FAINKKDTTRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTILDVGDAYFSIPL
DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTQILEPFRKKNPDIVV
CQYMDDLYVGSDLEIGQHRTKVKELREHLLKWGLTTPDQKYQREPPYLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLKGTKALTEVVPLTEEAE
LELAENREILKEPVHGAYYDPSKDLIVEIQKQGQGQWSYQIYQEPFKILKTGKYARTRSA
HTNDVRQLTEAVQKIATESIVIWGKTPKFKLPIQKETWDA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82A, L90M   L10I, K20KR, E35D, M36I, N37D, I62V, L63P, A71V, I72IM, I93L, C95F  
>1412-30312| codons 1-99
PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDIDLPGRWKPKMIGGIGGFVKVRQYD
QVPIEICGHKVMGTVLVGPTPANIIGRNLMTQLGFTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006