Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1412 | 1412-30312 | Denmark | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69T_T, K70R, L74V | K219Q, N348I | Y181C | V108I | V35R, T39A, K49KR, V60I, K64N, S68T, V118I, I135T, K166KQ, Q174K, I180IV, I202V, E203K, Q207E, R211K, F214L, H221Y, K223R, F227FY, A272P, R284K, I293V, V317A, A327V, T338S, M357T, G359S, K366R, E399D |
| >1412-30312| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALREICAEMEKEGKISRIGPENPYNTPI FAINKKDTTRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTILDVGDAYFSIPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTQILEPFRKKNPDIVV CQYMDDLYVGSDLEIGQHRTKVKELREHLLKWGLTTPDQKYQREPPYLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLKGTKALTEVVPLTEEAE LELAENREILKEPVHGAYYDPSKDLIVEIQKQGQGQWSYQIYQEPFKILKTGKYARTRSA HTNDVRQLTEAVQKIATESIVIWGKTPKFKLPIQKETWDA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L10I, K20KR, E35D, M36I, N37D, I62V, L63P, A71V, I72IM, I93L, C95F |
| >1412-30312| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDIDLPGRWKPKMIGGIGGFVKVRQYD QVPIEICGHKVMGTVLVGPTPANIIGRNLMTQLGFTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |