<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1411 1411-30312 Denmark 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A, L90M L33F, K43KT, G73T L10I, I13V, L19I, N37D, F53W, L63P, A71V, I93L  
>1411-30312| codons 1-99
PQITLWQRPIVTVKIGGQIKEALLDTGADDTVFEEMDLPGRWTPKIIGGIGGWVKVRQYD
QIPIEICGHKVITTVLVGPTPANIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184V, L210W, T215Y K219Q V106M, Y181C, G190A F227FL P1L, K20R, K32KT, T39A, E44ED, V60I, K101Q, K122E, I135T, Q174E, I202V, K223T, A272P, E297K, V317A, Q334L, K347KE, G359S, K390R, E399D, A400T  
>1411-30312| codons 1-400
LISPIETVPVKLKPGMDGPRVKQWPLTEEKITALVEICAELEKDGKISKIGPENPYNTPI
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSMTVLDVGDAYFSVPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKENPDIVI
CQYVDDLYVASDLEIGQHRTKVEELRQHLWRWGFYTPDQKHQTEPPLLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTKEAE
LELAENREILKEPVHGAYYDPSKDLIAEIQKQGLGQWTYQIYQEPFENLKTGKYARMRSA
HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWDT

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006