Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1411 | 1411-30312 | Denmark | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | L33F, K43KT, G73T | L10I, I13V, L19I, N37D, F53W, L63P, A71V, I93L |
| >1411-30312| codons 1-99 PQITLWQRPIVTVKIGGQIKEALLDTGADDTVFEEMDLPGRWTPKIIGGIGGWVKVRQYD QIPIEICGHKVITTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K219Q | V106M, Y181C, G190A | F227FL | K20R, K32KT, T39A, E44ED, V60I, K101Q, K122E, I135T, Q174E, I202V, K223T, A272P, E297K, V317A, Q334L, K347KE, G359S, K390R, E399D |
| >1411-30312| codons 2-399 ISPIETVPVKLKPGMDGPRVKQWPLTEEKITALVEICAELEKDGKISKIGPENPYNTPIF AIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSMTVLDVGDAYFSVPLD EDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKENPDIVIC QYVDDLYVASDLEIGQHRTKVEELRQHLWRWGFYTPDQKHQTEPPLLWMGYELHPDKWTV QPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTKEAEL ELAENREILKEPVHGAYYDPSKDLIAEIQKQGLGQWTYQIYQEPFENLKTGKYARMRSAH TNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |