<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1410 1410-30311 Denmark 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48A, I54A, V82T, L90M K43KT L10I, I15V, K20R, E35D, M36I, N37D, R57K, D60E, Q61QR, L63P, A71I, I72V, I93L  
>1410-30311| codons 1-99
PQITLWQRPIVTIKVGGQLREALLDTGADDTVLEDIDLPGRWTPKMIAGIGGFAKVKQYE
RIPIEICGHKIVGTVLVGPTPTNIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, M184V, L210W, T215Y N348NI K103N V108VI T7TP, V8I, V35R, T39A, R83K, K122E, Q174R, I178FL, G196E, I202IV, Q207E, R211K, A272P, L283LI, T286TN, D324DE, I329V, Q334QL, M357T, G359GS, A371AV, A400AT  
>1410-30311| codons 1-400
PISPIEPIPVKLKPGMDGPKVKQWPLTEEKIKALREICAELEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDLVI
YQYVDDLYVGSDLEIEQHRTKVEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGNKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKELIAEVQKQGLGQWTYQIYQEPFKILKTGKYARTRSA
HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWET

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006