Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1410 | 1410-30311 | Denmark | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48A, I54A, V82T, L90M | K43KT | L10I, I15V, K20R, E35D, M36I, N37D, R57K, D60E, Q61QR, L63P, A71I, I72V, I93L |
| >1410-30311| codons 1-99 PQITLWQRPIVTIKVGGQLREALLDTGADDTVLEDIDLPGRWTPKMIAGIGGFAKVKQYE RIPIEICGHKIVGTVLVGPTPTNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | N348NI | K103N | V108VI | T7TP, V8I, V35R, T39A, R83K, K122E, Q174R, I178FL, G196E, I202IV, Q207E, R211K, A272P, L283LI, T286TN, D324DE, I329V, Q334QL, M357T, G359GS, A371AV, A400AT |
| >1410-30311| codons 1-400 PISPIEPIPVKLKPGMDGPKVKQWPLTEEKIKALREICAELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDLVI YQYVDDLYVGSDLEIEQHRTKVEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGNKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKELIAEVQKQGLGQWTYQIYQEPFKILKTGKYARTRSA HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWET |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |