Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1407 | 1407-30410 | Denmark | 2003 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L10FI, K43T | T12PS, I15V, L19IK, K20I, E35D, M36I, R41K, D60E, Q61E, I62IV, L63P, H69K, A71V, I85V, I93L |
| >1407-30410| codons 1-99 PQITLWQRPIVSIKVGGQKIEALLDTGADDTVLEDINLPGKWTPKMIGGIGGFVKVRQYE EVPIEICGKKVIGTVLVGPTPANIVGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | V75VL, K219R | V106M | V179D, F227L | E6K, V35M, T39D, E44D, V118I, K122E, I135L, K173AT, Q174KR, N175Y, D177DE, E194K, G196E, T200A, I202V, Q207E, R211K, V245Q, D250E, A272S, K281R, T286A, E291D, V292I, I293V, H315F, Q334H, G335D, R356K, G359T, A371V, T377M, T386I, K390R |
| >1407-30410| codons 1-399 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALMEICDELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLLDFRELNKRTQDFWEVQLGIPHPAGLKKKKSMTVLDVGDAYFSIPL DEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTRYPEIDI YQYMDDLYVGSDLKIEQHRAKVEELREHLWKWGFYTPDRKHQKEPPLLWMGYELHPDKWT VQPIQLPEKESWTVNDIQKLVGKLNWASQIYSGIKVKQLCRLLRGAKALTDIVPLTEEAE LELAENREILKEPVFGVYYDPSKDLIAEIQKQGHDQWTYQIYQEPFKNLKTGKYAKMRTA HTNDVKQLTEVVQKIAMESIVIWGKIPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |