<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1407 1407-30410 Denmark 2003 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82A, L90M L10FI, K43T T12PS, I15V, L19IK, K20I, E35D, M36I, R41K, D60E, Q61E, I62IV, L63P, H69K, A71V, I85V, I93L  
>1407-30410| codons 1-99
PQITLWQRPIVSIKVGGQKIEALLDTGADDTVLEDINLPGKWTPKMIGGIGGFVKVRQYE
EVPIEICGKKVIGTVLVGPTPANIVGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L210W, T215Y V75VL, K219R V106M V179D, F227L E6K, V35M, T39D, E44D, V118I, K122E, I135L, K173AT, Q174KR, N175Y, D177DE, E194K, G196E, T200A, I202V, Q207E, R211K, V245Q, D250E, A272S, K281R, T286A, E291D, V292I, I293V, H315F, Q334H, G335D, R356K, G359T, A371V, T377M, T386I, K390R  
>1407-30410| codons 1-399
PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALMEICDELEKDGKISKIGPENPYNTPV
FAIKKKNSTKWRKLLDFRELNKRTQDFWEVQLGIPHPAGLKKKKSMTVLDVGDAYFSIPL
DEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTRYPEIDI
YQYMDDLYVGSDLKIEQHRAKVEELREHLWKWGFYTPDRKHQKEPPLLWMGYELHPDKWT
VQPIQLPEKESWTVNDIQKLVGKLNWASQIYSGIKVKQLCRLLRGAKALTDIVPLTEEAE
LELAENREILKEPVFGVYYDPSKDLIAEIQKQGHDQWTYQIYQEPFKNLKTGKYAKMRTA
HTNDVKQLTEVVQKIAMESIVIWGKIPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006