Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1406 | 1406-30326 | Denmark | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, M184MV, L210W, T215Y | K219R | K103N | V108I, F227L | P4S, K20R, T39A, K43Q, E44D, V118I, K122E, K166R, G196E, I202V, E203K, E204ED, Q207E, H208Y, R211K, W212M, H221Y, K223E, L228H, A272P, K277R, Q278H, T286A, E297A, S322T, Q334D, G335S, R356K, A376S, S379C, K390R, E399D, A400S |
| >1406-30326| codons 1-400 PISSIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEQDGKISKIGPENPYNTPV FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKVKDLREYLWKMGFYTPDRKYQEEPPLHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRHLCKLLRGAKALTEVIPLTAEAE LELAENREILKEPVHGVYYDPTKDLIAEIQKQGDSQWTYQIYQEPFKNLKTGKYAKMRGA HTNDVKQLTEAVQKISTECIVIWGKTPKFRLPIQKETWDS |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82S, L90M | K43T | L10I, K20R, E35D, M36I, N37D, Q61E, I62V, L63P, A71V, T74TS, V77I, I93L |
| >1406-30326| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDIDLPGRWTPKMIVGIGGFVKVRQYD EVPIEICGHKVIGSVLIGPTPSNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |