<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1406 1406-30326 Denmark 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I54V, V82S, L90M K43T L10I, K20R, E35D, M36I, N37D, Q61E, I62V, L63P, A71V, T74TS, V77I, I93L  
>1406-30326| codons 1-99
PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDIDLPGRWTPKMIVGIGGFVKVRQYD
EVPIEICGHKVIGSVLIGPTPSNIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L74V, M184MV, L210W, T215Y K219R K103N V108I, F227L P4S, K20R, T39A, K43Q, E44D, V118I, K122E, K166R, G196E, I202V, E203K, E204ED, Q207E, H208Y, R211K, W212M, H221Y, K223E, L228H, A272P, K277R, Q278H, T286A, E297A, S322T, Q334D, G335S, R356K, A376S, S379C, K390R, E399D, A400S  
>1406-30326| codons 1-400
PISSIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEQDGKISKIGPENPYNTPV
FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI
YQYVDDLYVGSDLEIEQHRTKVKDLREYLWKMGFYTPDRKYQEEPPLHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRHLCKLLRGAKALTEVIPLTAEAE
LELAENREILKEPVHGVYYDPTKDLIAEIQKQGDSQWTYQIYQEPFKNLKTGKYAKMRGA
HTNDVKQLTEAVQKISTECIVIWGKTPKFRLPIQKETWDS

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006