Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1405 | 1405-30227 | Denmark | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48A, I54V, V82A | L24I, Q58E | L10I, K20R, E35D, M36I, R41K, G51A, F53Y, K55KR, R57RK, D60E, Q61E, L63P, A71V, I72V | G17GR |
| >1405-30227| codons 1-99 PQITLWQRPIVTIKIGRQLREALIDTGADDTVLEDINLPGKWKPKIIAGIAGYVRVKEYE EIPIEICGHKVVGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, V75M, L210W, T215F | K219Q, N348I | K103N, Y181C | V108VI | T39TA, K43N, V60I, K122E, I135L, G196E, T200A, E203V, Q207E, D218E, L228R, A272AP, A288S, V317A, G359S, K366R, E399ED |
| >1405-30227| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELENEGKISKIGPENPYNTPI FAIKKKNSDRWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL DEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVGSDLEIEQHRAKIVELREHLWRWGFFTPEQKHQKEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKSLTEVIPLTEEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKILKTGKYARMRSA HTNDVRQLTEAVQKIATESIVIWGKTPKFKLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |