<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1404 1404-30724 Denmark 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA
2 NRTI+NNRTI+RTV+TPV 21

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, L76V, V82T L24I L10I, I15V, K20R, E35D, M36I, N37D, K55R, R57K, I62V, L63P, I64IV, A71V, I72T, I93L  
>1404-30724| codons 1-99
PQITLWQRPIVTIKVGGQLREALIDTGADDTVLEDIDLPGRWKPKIIGGIGGFVRVKQYD
QVPVEICGHKVTGTVVVGPTPTNIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74I, M184V, L210W, T215Y D67G, K219N K103N, Y181YC   V35VI, T39A, K43KQ, E44D, S68G, T107TS, V118I, D121C, K122E, I135T, V179VI, T200A, I202V, E203D, H208Y, R211K, D218DE, K223KE, D237E, A272P, T286A, A288S, T296S, E297R, V317A, A327V, E328D, P345E, A355E, M357T, K390R  
>1404-30724| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEQDGKISKIGPENPYNTPV
FAIKKKGGTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVSVLDVGDAYFSIPL
CEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII
CQYVDDLYVGSDLEIGQHRAKVDELRQYLWKWGFYTPENKHQEEPPFLWMGYELHPEKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKSLTEVIPLSREAE
LELAENREILKEPVHGAYYDPSKDLIVDIQKQGQGQWTYQIYQEEFKNLKTGKYERTRGA
HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006