Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1404 | 1404-30724 | Denmark | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 21 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82T | L24I | L10I, I15V, K20R, E35D, M36I, N37D, K55R, R57K, I62V, L63P, I64IV, A71V, I72T, I93L |
| >1404-30724| codons 1-99 PQITLWQRPIVTIKVGGQLREALIDTGADDTVLEDIDLPGRWKPKIIGGIGGFVRVKQYD QVPVEICGHKVTGTVVVGPTPTNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74I, M184V, L210W, T215Y | D67G, K219N | K103N, Y181YC | V35VI, T39A, K43KQ, E44D, S68G, T107TS, V118I, D121C, K122E, I135T, V179VI, T200A, I202V, E203D, H208Y, R211K, D218DE, K223KE, D237E, A272P, T286A, A288S, T296S, E297R, V317A, A327V, E328D, P345E, A355E, M357T, K390R, A400T |
| >1404-30724| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEQDGKISKIGPENPYNTPV FAIKKKGGTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVSVLDVGDAYFSIPL CEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII CQYVDDLYVGSDLEIGQHRAKVDELRQYLWKWGFYTPENKHQEEPPFLWMGYELHPEKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKSLTEVIPLSREAE LELAENREILKEPVHGAYYDPSKDLIVDIQKQGQGQWTYQIYQEEFKNLKTGKYERTRGA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWET |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |