Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1401 | 1401-30716 | Denmark | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 21 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, I54V, V82T, L90M | V11I, F53FL, G73S | L10I, I15V, K20I, M36I, R41K, K55R, Q61H, I62V, L63P, C67F, A71I, I72V, I85V, Q92K |
| >1401-30716| codons 1-99 PQITLWQRPIITIKVGGQLIEALLDTGADDTVLEEINLPGKWKPKIIGGVGGLVRVRQYD HVPIEIFGHKIVSTVLVGPTPTNIVGRNLMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K219N | K103N, Y181C, G190A | E138EK | E6D, K20KR, K43Q, E44D, K65K_N, K101Q, V118I, K122E, T200A, E203V, Q207E, H208Y, R211K, K223E, L228HR, A272P, I293V, K311R, V317A, Q334L, R356K, G359S, V365I, K390R |
| >1401-30716| codons 1-399 PISPIDTVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEQDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLQKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNKTPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVASDLEIGQHRAKIVELREYLWKWGFYTPDNKHQEEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILREPVHGAYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDIKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |