<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1401 1401-30219 Denmark 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I50V, I54V, V82T, L90M V11I, F53FL, G73S L10I, I15V, L19LQ, K20I, E21EQ, M36I, R41K, K55R, Q61H, I62V, L63P, C67F, A71I, I72V, I85V, Q92K  
>1401-30219| codons 1-99
PQITLWQRPIITIKVGGQQIQALLDTGADDTVLEEINLPGKWKPKIIGGVGGLVRVRQYD
HVPIEIFGHKIVSTVLVGPTPTNIVGRNLMTKIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184MV, L210W, T215Y K219N K103N, Y181C, G190A   E6D, K20KR, K43Q, E44D, K101Q, V118I, K122E, T200A, E203V, Q207E, H208Y, R211K, K223E, L228H, A272P, I293V, K311R, V317A, Q334L, R356K, M357MT, G359S, V365I, K390R  
>1401-30219| codons 1-399
PISPIDTVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEQDGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLQKNKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
CQYVDDLYVASDLEIGQHRAKIVELREYLWKWGFYTPDNKHQEEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE
LELAENREILREPVHGAYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKNLKTGKYAKTRSA
HTNDIKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006