Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1273 | 1273-30904 | Belgium | 2003 | HIV1 | G | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, V82T, I84V | K43T, F53L, L89V | L10I, I13A, K14R, K20V, A22V, M36I, N37D, R41K, L63P, I66V, H69K, A71V, T74S | T91TCS |
| >1273-30904| codons 1-98 PQITLWQRPIVTARIGGQLVEVLLDTGADDTVLEEIDLPGKWTPKIVGGIGGLVKVRQYD QIPIEVCGKKVIGSVLVGPTPTNVIGRNVLSQIGCTLN |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, M184V, T215F | K219Q | K103N | F227L | V35T, E42EK, K49KR, V60I, T69N, V90I, K122E, D123S, A158S, E169D, K173R, Q174K, D177E, I178M, G196E, T200A, E203A, Q207E, H208Y, R211K, D218E, L228LH, V245Q, E248D, D250E, A272P, T286A, V292I, I293V, E297A, D324E, I329V, Q334P, G335D, F346Y, R356K, M357R, R358G, G359S, A371V, Q394R |
| >1273-30904| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELKKEGKISRIGPENPYNTPI FAIKKKNSNRWRKIVDFRELNKRTQDFWEIQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILDPFRRKNPEMVI YQYVDDLYVGSDLEIEQHRAKIAELREYLLKWGFFTPEQKHQKEPPLHWMGYELHPDKWT VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEIVPLTAEAE LELAENREILKEPVHGVYYDPSKELIAEVQKQGPDQWTYQIYQEPYKNLKTGKYAKRGSA HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIRKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |