<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-1271 1271-30923 Belgium 2003 HIV1 F Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I54V, V82S L24I, L33F, Q58E L10I, I15V, G16E, K20R, E34Q, E35D, M36I, P39PT, R41K, R57K, I62V, L63T, E65D, I72T, L89M  
>1271-30923| codons 1-99
PQITLWQRPIVTIKVEGQLREALIDTGADDTVFQDINLTGKWKPKMIVGIGGFVKVKEYD
QVTIDICGHKATGTVLVGPTPSNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69S_SS, L210W, T215Y A62V, V75I, F116Y K103N, Y181YC V108I, K238T P4PS, K20R, V35T, K43Q, E44D, K49KR, K122P, D123E, I135IV, S162CY, E169D, K173A, Q174K, D177E, I178L, E203K, Q207E, R211K, K223Q, L228H, V245Q, E248D, A272P, K277R, Q278N, L283I, T286A, E291D, V292I, I293V, P294T, E297A, Q334L, R356K, G359S, A371V, I375V, T377R, I382V, K390R  
>1271-30923| codons 1-400
PISSIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICTELEQDGKISRIGPENPYNTPV
FVIKKKDSSKWRKLIDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYYSVPL
DPEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILDPFRAKNPELVI
CQYMDDLYVGSDLEIGQHRTKIKELREHLWKWGFYTPDKKHQQEPPFHWMGYELHPDTWT
VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVRNLCKLIRGAKALTDIVTLTAEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKNLKTGKYAKMRSA
HTNDVKQLTEVVQKVARESIVVWGKTPKFRLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006