Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1271 | 1271-30923 | Belgium | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82S | L24I, L33F, Q58E | L10I, I15V, G16E, K20R, E34Q, E35D, M36I, P39PT, R41K, R57K, I62V, L63T, E65D, I72T, L89M |
| >1271-30923| codons 1-99 PQITLWQRPIVTIKVEGQLREALIDTGADDTVFQDINLTGKWKPKMIVGIGGFVKVKEYD QVTIDICGHKATGTVLVGPTPSNIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69S_SS, L210W, T215Y | A62V, V75I, F116Y | K103N, Y181YC | V108I, K238T | P4PS, K20R, V35T, K43Q, E44D, K49KR, K122P, D123E, I135IV, S162CY, E169D, K173A, Q174K, D177E, I178L, E203K, Q207E, R211K, K223Q, L228H, V245Q, E248D, A272P, K277R, Q278N, L283I, T286A, E291D, V292I, I293V, P294T, E297A, Q334L, R356K, G359S, A371V, I375V, T377R, I382V, K390R |
| >1271-30923| codons 1-400 PISSIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICTELEQDGKISRIGPENPYNTPV FVIKKKDSSKWRKLIDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYYSVPL DPEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILDPFRAKNPELVI CQYMDDLYVGSDLEIGQHRTKIKELREHLWKWGFYTPDKKHQQEPPFHWMGYELHPDTWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVRNLCKLIRGAKALTDIVTLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLTEVVQKVARESIVVWGKTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |