Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-1270 | 1270-30923 | Belgium | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74IV, M184V, T215F | K219Q | Y181C, G190A | K20KR, V35L, T39A, K43KE, A98S, K101Q, K122E, D123S, S162D, H208Y, R211K, D218E, L228H, Q242H, A272P, V292I, I293V, P294T, Q334P, M357S, A376T, T386TS, K390R |
| >1270-30923| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICAELEEEGKISKIGPENPYNTPV FAIKKKNSTRWRKVVDFRELNKRTQDFWEVQLGIPHPSGLQKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDIVI CQYVDDLYVASDLEIGQHRTKIEELRQYLLKWGFFTPEQKHQKEPPFHWMGYELHPDKWT VHPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEIVTLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGPGQWTYQIYQEPFKNLKTGKYARSRGA HTNDVKQLTEAVQKITTESIVIWGKSPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | Q58E | L10V, L63P, I66V, H69R, I72IT, T74K, L89M, Q92K, I93M, C95F |
| >1270-30923| codons 1-99 PQITLWQRPVVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVREYD QIPIEVCGRKATGKVLVGPTPVNVIGRNMMTKMGFTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |